“We are a long way from having the evidence for the best treatment decisions with respect to resistance for a range of diseases,” Birger said.
From a study on a mice, scientists found that the high-dose drug treatment killed off the non-resistant malarial parasites, leaving the resistant strains to multiply and make the mice even sicker.
Taking a cue from the experiment on mice, the authors of the current study examined whether the same may be true for other types of microbes such as bacteria.
Finding the ideal dose and duration of treatment, one that cures the patient without aiding the spread of resistance, will likely be done on a disease by disease basis, the authors found.
Aggressive treatment might be best for pathogens that develop resistance slowly, over the course of several mutations. High-doses early in the process could be effective at heading off the development of resistance, concluded the researchers.
The study was published in the journal Proceedings of the Royal Society B
PIC used only for reference (Courtesy: Online Media Sources)